Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0099rc7.5 | Rapid Communications 7: Endocrine-related Cancer | ECE2024

Fibroblast-mediated modulation of GI-NETs: Implications for drmg response and tumor invasion

Malavasi Eleonora , Toffoli Lara , Dainotto Marilyn , Ditsiou Angeliki , Gagliano Teresa

Introduction: The intricate interplay between fibroblasts and cancer cells significantly contributes to cancer invasion, extracellular matrix (ECM) modulation, and the development of drmg resistance. This study delves into understanding the specific influence of fibroblasts on Gastro-Intestinal neuroendocrine tumor (GI-NET) cell lines.Materials and Methods: Utilizing GOT1 and COLO320 cell lines, we incorporated Normal Human Dermal Fibroblasts (NF) in our...
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ea0099p98 | Endocrine-Related Cancer | ECE2024

Targeting focal adhesion kinase (FAK) and spleen tyrosine kinase (SYK) in gastrointestinal neuroendocrine tumors: Unveiling mechanisms and anti-proliferative effects

Toffoli Lara , D'Este Francesca , Dainotto Marilyn , Ditsiou Angeliki , Gagliano Teresa

Gastrointestinal neuroendocrine tumors (GI-NETs) present a challenging and diverse landscape, necessitating effective treatment strategies. Despite advancements, the demand for targeted therapies, particularly for advanced or metastatic cases, persists. Enhancing outcomes in GI-NETs management is crucial, emphasizing the need for ongoing research and development. In our laboratory, we conducted a multitarget compound screening, identifying FAK (BI-0319) and SYK (BI1002494) kin...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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